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Low Dose Naltrexone

Low Dose Naltrexone (LDN)

What is Low Dose Naltrexone (LDN)?

Low Dose Naltrexone (LDN) is a compounded, low-dose version of the medication naltrexone, typically taken at 0.5–4.5 mg daily. Unlike its high-dose form used for addiction, LDN is used to boost the immune system, reduce inflammation, increase natural endorphins, and support healing in autoimmune and chronic conditions like Hashimoto’s, fibromyalgia, and Crohn’s disease.

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You have been prescribed Low Dose Naltrexone (LDN), typically in capsule form at doses between 0.5mg–4.5mg, sometimes higher. LDN is a modified use of a medication originally approved for opioid and alcohol use disorder, now compounded at much lower doses to support the immune system, reduce inflammation, and increase natural endorphins.

Many patients notice:

  • Improved sense of well-being
  • Reduced pain and inflammation
  • Better mood and energy
  • May support sleep and reduce anxiety (depending on timing)

With regular use, naltrexone:

  • Modulates the immune system in conditions like Hashimoto’s, Crohn’s, MS, fibromyalgia, and others
  • May help reduce frequency/severity of autoimmune flares
  • Increases natural endorphins and enkephalins
  • Can support healing and emotional balance over time
  • Continue lab testing based on your condition and provider’s guidance
  • LDN may cause false positives on some urine drug screens (especially for opioids)
  • If on thyroid medication, watch for signs of increased thyroid sensitivity
  • Vivid dreams or insomnia (especially if taken at night—can switch to AM dosing)
  • Severe or prolonged nausea, vomiting, or flu-like symptoms
  • Symptoms of opioid withdrawal (if recently using narcotics)
  • Sudden changes in mood, sleep, or energy that are distressing
  • New or worsening autoimmune symptoms
  • Severe or prolonged nausea, vomiting, or flu-like symptoms
  • Symptoms of opioid withdrawal (if recently using narcotics)
  • Sudden changes in mood, sleep, or energy that are distressing
  • New or worsening autoimmune symptoms
  • Do not take LDN with opioid medications—it can block their effect or cause withdrawal
  • Avoid if pregnant or breastfeeding (safety not established)
  • If taking thyroid medication, monitor for increased sensitivity
  • Do not use oral and topical LDN formulations at the same time without medical advice
  • Discuss surgery timing with your doctor—LDN should be stopped 24 hours before planned surgery
  • Typically, take one dose daily at bedtime.
  • May switch to AM dosing for a few weekd if you experience vivid dreams or insomnia

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The information and videos found here are for educational purposes only and do not replace a consultation with a pharmacist. For personalized guidance, please contact us to speak directly with a pharmacist about your medication.

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Disclaimer:
The drug information provided is for informational and educational purposes only. The products or formulations discussed may not be approved by the U.S. Food and Drug Administration (FDA). This information is not intended to diagnose, treat, cure, or prevent any disease, nor does it replace a consultation with a qualified pharmacist or healthcare provider. Always seek the advice of your healthcare professional regarding any questions you may have about a medication or treatment.

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