Bioidentical hormones have some distinctly different, potentially opposite, physiological effects compared with their synthetic counterparts, which have different chemical structures. Synthetic progestins have a variety of negative cardiovascular effects and an increased risk of breast cancer, as compared to the physiological and clinical data indicating progesterone is associated with a diminished risk for breast cancer. Estriol has some unique physiological effects, which differentiate it from estradiol, estrone, and CEE. Estriol would be expected to carry less risk for breast cancer.
In conclusion, physiological data and clinical outcomes demonstrate bioidentical hormones are associated with lower risks, including the risk of breast cancer and cardiovascular disease, and are more effective than their synthetic and animal-derived counterparts. Until evidence is found to the contrary, bioidentical hormones remain the preferred method of HRT (Postgrad Med. 2009 Jan;121(1):73-85.)
Working with you and your prescriber, our compounding pharmacy can prepare hormones in a variety of strengths and dosage forms, including topical or vaginal creams, capsules, sublingual drops or troches, and suppositories. Contact us directly for more information.