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Progesterone

What is Progesterone?

Progesterone is a natural hormone made by the ovaries that helps regulate the menstrual cycle, supports pregnancy, and balances the effects of estrogen. It also promotes sleep, calms the nervous system, and supports bone, brain, and thyroid health. Bioidentical progesterone is often used in hormone therapy to balance estrogen and relieve symptoms like insomnia, anxiety, and PMS.

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Your doctor prescribed Progesterone, a bioidentical hormone often derived from wild yam and compounded into a cream, capsule, or lozenge. It is identical to the progesterone your body naturally produces and is prescribed to balance estrogen and support many body functions.

Within a few weeks to months, you may notice:

  • Improved sleep (especially with oral or sublingual forms)
  • Calmer mood and reduced anxiety
  • Relief from PMS or perimenopausal symptoms
  • Less breast tenderness and bloating

Progesterone balances estrogen, helping to reduce risks linked to excess estrogen (e.g., fibroids, endometrial issues)

With continued use, progesterone therapy may help support:

  • Bone density and osteoporosis risk
  • Thyroid efficiency and energy
  • Brain function and mood
  • Routine Pap smear and breast exams
  • Lab testing is usually done at baseline, 1–3 months in, and then every 3-6 months.
  • Avoid drawing blood near the application site
  • Common labs: Estradiol and/or Estrone, Progesterone, Testosterone, SHBG, FSH/LH
  • Drowsiness or grogginess (especially with oral use—best taken at bedtime)
  • Bloating, fatigue, or weight gain
  • Low blood pressure or dizziness
  • Mood changes like irritability or depression (rare; may require dose/form change)
  • Vertigo, increased appetite, or breast tenderness
  • New depression or suicidal thoughts
  • Severe dizziness or fainting
  • Sudden swelling or leg pain (possible clot)
  • Unusual vaginal bleeding
  • Severe skin rash or allergic reaction

Do not use if you have:

  • Undiagnosed vaginal bleeding
  • Breast cancer
  • Blood clots or history of stroke
  • Severe liver dysfunction
  • Wash hands thoroughly after applying creams
  • Avoid direct contact with others on the application site for several hours
  • Use as indicated by your doctor.
  • Take capsules at bedtime.

For more instruction on how to use your topical medication, select the device you recevied:

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The information and videos found here are for educational purposes only and do not replace a consultation with a pharmacist. For personalized guidance, please contact us to speak directly with a pharmacist about your medication.

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Disclaimer:
The drug information provided is for informational and educational purposes only. The products or formulations discussed may not be approved by the U.S. Food and Drug Administration (FDA). This information is not intended to diagnose, treat, cure, or prevent any disease, nor does it replace a consultation with a qualified pharmacist or healthcare provider. Always seek the advice of your healthcare professional regarding any questions you may have about a medication or treatment.

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