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Vaginal Estrogens

Estrogen Vaginal (Estriol or Estradiol)

What are Vaginal Estrogens?

Vaginal estrogens are low-dose estrogen medications applied inside the vagina to treat local menopausal symptoms like dryness, burning, itching, and painful intercourse. They come as creams, tablets, or suppositories.

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Your doctor has prescribed vaginal estrogen therapy (either estradiol or estriol) as a cream or suppository. These are bioidentical hormones designed to help restore vaginal and urinary health by replacing the estrogen your body no longer makes after menopause.

Most patients notice relief within a few weeks, including:

  • Less vaginal dryness or irritation
  • Reduced pain during intercourse
  • Fewer urinary issues (urgency, burning, leakage)
  • Improved comfort and overall vaginal health

With regular use, vaginal estrogen may:

  • Restore healthy vaginal tissue and pH
  • Prevent recurring urinary tract infections
  • Support bladder and pelvic health
  • Improve overall quality of life with minimal systemic hormone exposure
  • Routine labs are usually not needed for vaginal estrogen.
  • Continue with yearly Pap smears and breast exams as recommended by your doctor.

Most women tolerate treatment well. Possible side effects may include:

  • Mild vaginal irritation, discharge, or spotting
  • Breast tenderness or bloating
  • Headaches or mood changes
  • Skin changes at the application site
  • Unusual or heavy vaginal bleeding
  • Pelvic pain
  • Signs of infection (odor, itching, or burning)
  • Yellowing of eyes or skin, or swelling in hands/feet

Let your provider know if you have a history of breast cancer, unexplained vaginal bleeding, or are pregnant or breastfeeding

  • Use as indicated by your doctor.
  • Use at bedtime to help the medicine stay in place
  • Avoid sex immediately after application to reduce transfer to your partner
  • Wash hands well after use
  • Do not use tampons while on vaginal estrogen
  • Store suppositories in the fridge so they don’t melt

For more instruction on how to use your medication, select the device you recevied:

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The information and videos found here are for educational purposes only and do not replace a consultation with a pharmacist. For personalized guidance, please contact us to speak directly with a pharmacist about your medication.

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Disclaimer:
The drug information provided is for informational and educational purposes only. The products or formulations discussed may not be approved by the U.S. Food and Drug Administration (FDA). This information is not intended to diagnose, treat, cure, or prevent any disease, nor does it replace a consultation with a qualified pharmacist or healthcare provider. Always seek the advice of your healthcare professional regarding any questions you may have about a medication or treatment.

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