What is Incontinence?
Sixty-two women with stress urinary incontinence were randomized to perform pelvic floor muscle training (PFMT), electrical stimulation (ES), and biofeedback (Group 1) or the same treatment combined with an intravaginal estriol 1mg formulation for 6 months. Mean urine leakage using a 24-hour pad test dropped from 42.3 +/- 20.2g/die to 31.5 +/- 14.2g/die in Group 1, and from 48.3 +/- 19.8g/die to 22.3 +/- 10.1g/die in the Estriol group. Symptoms as well as incontinence were significantly better in the group treated with Estriol.1
In another study of 60 postmenopausal women with stage I and II stress urinary incontinence, estriol 0.5mg was co-administered with vitamin D3 12,500 IU intravaginally 3 times a week for 6 weeks after subjects failed a 6-week treatment of estriol 0.5 mg + PFMT. High dosed vitamin D may help improve effects of local estriol. The results of the study showed complete remission of urinary incontinence in 1/3 of the women and another 1/3 of the women studied showed a 75% improvement in urinary retention.2
In an open, prospective, multicenter, controlled study, 629 women suffering from stress and urgency urinary incontinence were treated with vaginally estriol at a dose of 10 mg daily for 3 weeks, and 10mg twice weekly for another 3 weeks. Of the 629 women who started the study, 552 were available for follow-up after 6-weeks of treatment. Subjective improvements in symptoms of stress urinary incontinence (SUI) were 82% for grade 1, 77% for grade 2, and 69% for grade 3. Voluntary urinary control and symptoms of urgency were improved in more than 80% of patients, and frequency was reduced in almost 50% of women. Compared with conditions at the outset of the study, after 6 weeks, vaginal lubrication was normalized in 77%, and intercourse was no longer painful for 88% of women.3
Estriol is an approved drug in many countries around the world as a vaginal pessary and cream. In the US, however, estriol cream is not available commercially and must be specifically compounded for patients. Fortunately, here at Harbor Compounding Pharmacy, we specialize in women’s health and hormone replacement strategies. We are a valued and trusted source for bioidentical hormone formulations including vaginal estriol creams. If you are in menopause and suffer from urinary retention and wish to try one of Harbor’s estriol vaginal formulations, call today to speak to one of our pharmacists. We will be able to either request an estriol prescription from your provider or recommend you to one of our trusted hormone practitioners.
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- Castellani D, Saldutto P, Galica V, et al. Low-Dose Intravaginal Estriol and Pelvic Floor Rehabilitation in Post-Menopausal Stress Urinary Incontinence. Urol Int. 2015;95(4):417-421.
- Schulte-Uebbing C, Schlett S, Craiut D, Bumbu G. Stage I and II Stress Incontinence (SIC): High dosed vitamin D may improve effects of local estriol. Dermatoendocrinol. 2016;8(1)
- Schmidbauer CP. Vaginale Ostriolapplikation zur Behandlung der postmenopausalen Harninkontinenz [Vaginal estriol administration in treatment of postmenopausal urinary incontinence]. Urologe A. 1992;31(6):384-389
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